Publications

Biostatistics and biomedical data science in practice.

Selected publications spanning causal inference, precision medicine, clinical AI, biomedical informatics, microbiome, and multi-omics. For the complete and most current record, visit Google Scholar.

202601

EMNLP

Making Clinical Language Models Auditable: Concept-Guided Fine-Tuning for Robust Prediction

Mu J, Chen G†

Clinical AI

Paper

202602

Statistics in Medicine

Confidence Interval Construction for Causally Generalized Estimates with Target Sample Summary Information

Chen Y, Chen G, Yu M

Causal inference

Paper

202503

npj Digital Medicine

Mixture-of-Multimodal-Agents (MoMA) Architecture for Enhancing Clinical Prediction Modeling

Gao J, Rahman M, Caskey J, Oguss M, O’Rourke A, Brown R, Mayampurath A, Churpek MM, Chen G†, Afshar M†

Clinical AI

Paper

202504

Genome Biology

Fast and Reliable Association Discovery in Large-Scale Microbiome Studies and Meta-Analyses Using PALM

Wei Z, Hong Q, Chen G, Hartert T, Rosas-Salazar C, Das S, Shilts M, Levin A, Tang ZZ

Microbiome

Paper

202405

NeurIPS

An Effective Framework for Estimating Individualized Treatment Rules

Lee J, Huling JD, Chen G†

Precision medicine

Paper Code

202606

Journal of Biomedical Informatics

Explainable Multimodal Deep Learning for Variable-Length Clinical Sequences

Martin J, et al., Chen G

Clinical AI

Paper

202507

Bioinformatics

Multidimensional Scaling Improves Distance-Based Clustering for Microbiome Data

Chen G, Wang X, Sun Q, Tang ZZ

Microbiome

Paper Code

202508

Genome Biology

Melody: Meta-analysis of Microbiome Association Studies for Discovering Generalizable Microbial Signatures

Wei Z, Chen G, Tang ZZ

Microbiome

Paper

202509

npj Digital Medicine

Evaluating Clinical AI-Generated Summaries with Large Language Model Judges

Croxford E, et al., Chen G

Clinical AI

Paper

202510

EMNLP

Information-Theoretic Multi-LLM Uncertainty Estimation for Clinical Prediction

Kruse M, et al., Chen G

Clinical AI

Paper

202411

Journal of the American Statistical Association

Independence Weights for Causal Inference with Continuous Treatments

Huling JD, Greifer N, Chen G

Precision medicine

Paper Code

202412

Biometrika

Robust Sample Weighting to Facilitate Individualized Treatment Rule Learning for a Target Population

Chen R, Huling JD, Chen G, Yu M

Precision medicine

Paper

202413

Journal of the American Statistical Association

Minimum Resource Threshold Policy Under Partial Interference

Park C, Chen G, Yu M, Kang H

Precision medicine

Paper

202414

Journal of the American Medical Informatics Association

Fair Two-Year Stroke Risk Prediction in the All of Us Research Program

Gao J, et al., Chen G

Clinical AI

Paper

202415

Journal of the American Medical Informatics Association

Automated Trauma Severity Assessment Using Multimodal Machine Learning

Gao J, et al., Chen G

Clinical AI

Paper

202416

Journal of the American Medical Informatics Association

Crowd-Sourced Development of an Electronic Health Record Mortality Prediction Model

Bergquist T, et al., Gao J, Chen G

Clinical AI

Paper

202417

Statistical Science

Causal Inference Methods for Combining Randomized Trials and Observational Studies: A Review

Colnet B, et al., Chen G

Causal inference

Paper

202318

Biometrics

Entropy Balancing for Causal Generalization with Target Sample Summary Information

Chen R, Chen G, Yu M

Causal inference

Paper Code

202319

Genome Biology

PhyloMed: A Phylogeny-Based Test of Mediation Effects in Microbiome Studies

Hong Q, Chen G, Tang ZZ

Microbiome

Paper

202320

Annals of Applied Statistics

A Reluctant Additive Model Framework

Maronge JM, Huling JD, Chen G

Statistical methodology

Paper

202321

Biostatistics

A Generalizability Score for Applying Clinical Trial Results to Target Populations

Chen R, Chen G, Yu M

Causal inference

Paper Code

202322

Journal of Biomedical Informatics

A Hybrid System for Generating Clinical Assessments and Plans

Gao J, He S, Hu J, Chen G

Clinical AI

Paper

202323

Cancer Prevention Research

Hypothesized Versus Observed Effect Sizes in Cancer Prevention Research

Eickhoff JC, et al., Chen G

Biomedical applications

Paper

202224

AISTATS

Policy Learning for Individualized Dose Intervals

Chen G, Li X, Yu M

Precision medicine

Paper

202225

Machine Learning for Health

Meta-Analysis of Individualized Treatment Rules Using Sign-Coherency

Cheng J, Huling JD, Chen G

Precision medicine

Paper Code

202226

Journal of Clinical Oncology

Patient-Specific Covariates in Oncology Research: A Review

Xu R, Chen G, et al.

Biomedical applications

Paper

202227

JAMA Surgery

Sex-Adjusted and Sodium-Adjusted Model for End-Stage Liver Disease

Sealock JM, et al., Chen G, Davis LK

Biomedical applications

Paper

202128

Journal of the American Statistical Association

A Two-Part Framework for Individualized Treatment Rules

Huling JD, Smith MA, Chen G

Precision medicine

Paper Code

202129

JAMA Network Open

The COVID-19 Prediction DREAM Challenge

Yan L, et al., Gao J, Chen G

Clinical AI

Paper

202130

JAMA Psychiatry

PsycheMERGE Network Study of Depression Polygenic Risk and White Blood Cell Count

Sealock JM, et al., Chen G

Biomedical applications

Paper

201931

Biostatistics

Zero-Inflated Generalized Dirichlet Multinomial Regression for Microbiome Compositional Data

Tang ZZ, Chen G

Microbiome

Paper

201732

Biometrics

Greedy Outcome Weighted Tree Learning of Optimal Personalized Treatment Rules

Zhu R, Zhao YQ, Chen G, Ma S, Zhao H

Precision medicine

Paper

201733

Journal of the American Medical Informatics Association

Temporal Calibration of an Electronic Health Record Predictive Model for Acute Kidney Injury

Davis SE, et al., Chen G

Clinical AI

Paper

201634

Journal of the American Statistical Association

Personalized Dose Finding Using Outcome Weighted Learning

Chen G, Zeng D, Kosorok MR

Precision medicine

Paper

201635

Bioinformatics

PERMANOVA-S: Association Test for Microbial Community Composition that Accommodates Confounders and Multiple Distances

Tang ZZ, Chen G, et al.

Microbiome

Paper

201436

Nature Genetics

Heritability and Genomics of Gene Expression in Peripheral Blood

Wright FA, et al., Chen G

Biomedical applications

Paper

201337

Proceedings of the National Academy of Sciences

Biclustering with Heterogeneous Variance

Chen G, Sullivan PF, Kosorok MR

Statistical methodology

Paper Code